Author:
Barsky Daniel,Ben Ya’acov Ami,Avraham Linn Wagnert,Nachman Dean,Eisenkraft Arik,Mintz Yoav,Shteyer Eyal
Abstract
AbstractPenetrating abdominal injury is a major cause of death in trauma. Sodium alginate hydrogel, a hemostatic agent, offers a platform for targeting both mechanical and biological injuries. The current study assessed the effect of Very Low Viscosity (high) G (VLVG) alginate following abdominal trauma in a swine model of penetrating abdominal injury. Seven anesthetized pigs were instrumented with invasive monitoring catheters and abdominal trauma was introduced by laparoscopic hepatectomy. Ten minutes after the induction of hypovolemic shock, three animals were intra-abdominally administered with VLVG alginate (study group) and four animals with saline (control group). During 8 h of continuous monitoring, various hemodynamic and biochemical variables were measured and liver biopsies for histological evaluation were taken. Hemodynamically, VLVG alginate-treated animals were more stable than controls, as reflected by their lower heart rate and higher blood pressure (p < 0.05 for both). They also had lower levels of liver enzymes and lactate, and less histopathological damage. We show that VLVG alginate might be a promising new agent for reducing penetrating intra-abdominal injury, with hemostatic and biocompatibility efficiency, and tissue preserving properties. Future effort of integrating it with a dispersal device may turn it into a valuable pre-hospital emergency tool to improve survival of trauma casualties.
Publisher
Springer Science and Business Media LLC
Reference36 articles.
1. Schwartz, D. et al. Injury patterns of soldiers in the second Lebanon war. J. Trauma Acute Care Surg. 76, 160–166 (2014).
2. Leong, M. J., Edgar, I. & Terry, M. Penetrating abdominal injury: UK military experience from the Afghanistan conflict. J. R. Nav. Med. Serv. 102, 90–94 (2016).
3. Turner, C. A., Stockinger, Z. T. & Gurney, J. M. Combat surgical workload in operation iraqi freedom and operation enduring freedom: The definitive analysis. J. Trauma Acute Care Surg. 83, 77–83 (2017).
4. Iflazoglu, N., Ureyen, O., Oner, O. Z., Tusat, M. & Akcal, M. A. Complications and risk factors for mortality in penetrating abdominal firearm injuries: Analysis of 120 cases. Int. J. Clin. Exp. Med. 8, 6154–6162 (2015).
5. Chen, J., Ren, J., Zhang, W. & Li, J. Open versus closed abdomen treatment on liver function in rats with sepsis and abdominal compartment syndrome. J. Trauma 71, 1319–1325 (2011).
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