A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence
Author:
Funder
Lancaster University
Cancer & Polio Research Fund: http://www.cprf.org.uk/
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-019-41662-8.pdf
Reference45 articles.
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2. Li, Y., Zhu, R., Qian, Y. & Deng, J. The characteristics of blood glucose and WBC counts in peripheral blood of cases of hand foot and mouth disease in China: a systematic review. PLoS One 7, e29003 (2012).
3. Brown, B. A., Oberste, M. S., Alexander, J. P. Jr., Kennett, M. L. & Pallansch, M. A. Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998. J Virol 73, 9969–75 (1999).
4. Castro, C. M., Cruz, A. C., Silva, E. E. & Gomes Mde, L. Molecular and seroepidemiologic studies of Enterovirus 71 infection in the State of Para, Brazil. Rev Inst Med Trop Sao Paulo 47, 65–71 (2005).
5. Yip, C. C. et al. Genetic characterization of EV71 isolates from 2004 to 2010 reveals predominance and persistent circulation of the newly proposed genotype D and recent emergence of a distinct lineage of subgenotype C2 in Hong Kong. Virol J 10, 222 (2013).
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