Author:
Higazi Aliaa M.,Kamel Hanan M.,Abdel-Naeem Emad A.,Abdullah Noha M.,Mahrous Doaa M.,Osman Ashraf M.
Abstract
AbstractAutism Spectrum Disorder (ASD) and learning disabilities are neurodevelopmental disabilities characterized by dramatically increasing incidence rates, yet the exact etiology for these disabilities is not identified. Impairment in tryptophan metabolism has been suggested to participate in the pathogenesis of ASD, however, further validation of its involvement is required. Additionally, its role in learning disabilities is still uninvestigated. Our objective was to evaluate some aspects of tryptophan metabolism in ASD children (N = 45) compared to children with learning disabilities (N = 44) and healthy controls (N = 40) by measuring the expression levels of the MAOA, HAAO and AADAT genes using real-time RT-qPCR. We also aimed to correlate the expression patterns of these genes with parental ages at the time of childbirth, levels of serum iron, and vitamin D3 and zinc/copper ratio, as possible risk factors for ASD. Results demonstrated a significant decrease in the expression of the selected genes within ASD children (p < 0.001) relative to children with learning disabilities and healthy controls, which significantly associated with the levels of our targeted risk factors (p < 0.05) and negatively correlated to ASD scoring (p < 0.001). In conclusion, this study suggests that the expression of the MAOA, HAAO and AADAT genes may underpin the pathophysiology of ASD.
Funder
Faculty of Medicine, Minia University, Minia, Egypt
Publisher
Springer Science and Business Media LLC
Reference72 articles.
1. Autism spectrum disorders. Centers for disease control and prevention (CDC). https://www.cdc.gov/ncbddd/autism/data.html (2018).
2. American Psychiatric Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Pub. Association, (2013).
3. Cortiella, C. & Horowitz, S. H. The state of learning disabilities: Facts, trends and emerging issues. New York: National center for learning disabilities, 2–45 (2014).
4. University College London. "Learning disabilities affect up to 10 percent of children." ScienceDaily. ScienceDaily, 18 April 2013. www.sciencedaily.com/releases/2013/04/130418142309.htm.
5. Rylaarsdam, L. & Guemez-Gamboa, A. Genetic causes and modifiers of autism spectrum disorder. Front. Cell. Neurosci. 13, 385 (2019).
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