Author:
Imbeloni Aline Amaral,de Alcantara Bianca Nascimento,Coutinho Leandro Nassar,de Azevedo Scalercio Sarah Raphaella Rocha,Carneiro Liliane Almeida,Oliveira Karol Guimarães,Filho Arnaldo Jorge Martins,de Brito Simith Durans Darlene,da Silva Wellington Bandeira,Nunes Bruno Tardelli Diniz,Casseb Livia Medeiros Neves,Chiang Jannifer Oliveira,de Carvalho Carlos Alberto Marques,Machado Mariana Borges,Quaresma Juarez Antônio Simões,de Almeida Medeiros Daniele Barbosa,da Costa Vasconcelos Pedro Fernando
Abstract
AbstractDuring the Zika virus (ZIKV) outbreak in Brazil (2015–2016), the clinical manifestations associated with its infection were complex and included miscarriage and congenital malformations, not previously described. In this study, we evaluated the prenatal conditions of pregnant female squirrel monkeys (Saimiri collinsi) infected during different gestational thirds (GTs) and assessed all clinical aspects, diagnostic imaging, viremia and the immune response. In our study, 75% of the infected animals in the 1st GT group had significant clinical manifestations, such as miscarriage and prolonged viremia associated with a late immune response. Consequently, their neonates showed fetal neuropathology, such as cerebral hemorrhage, lissencephaly or malformations of the brain grooves, ventriculomegaly, and craniofacial malformations. Thus, our study demonstrated the relevance of pregnant squirrel monkeys as a model for the study of ZIKV infection in neonates due to the broad clinical manifestations presented, including the typical congenital Zika syndrome manifestations described in humans.
Publisher
Springer Science and Business Media LLC
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