Author:
Ogai Kazuhiro,Nana Benderli Christine,Lloyd Yukie Michelle,Arios John Paul,Jiyarom Boonyanudh,Awanakam Honore,Esemu Livo Forgu,Hori Aki,Matsuoka Ayaka,Nainu Firzan,Megnekou Rosette,Leke Rose Gana Fomban,Ekali Gabriel Loni,Okamoto Shigefumi,Kuraishi Takayuki
Abstract
AbstractThe commensal microbes of the skin have a significant impact on dermal physiology and pathophysiology. Racial and geographical differences in the skin microbiome are suggested and may play a role in the sensitivity to dermatological disorders, including infectious diseases. However, little is known about the skin microbiome profiles of people living in Central Africa, where severe tropical infectious diseases impose a burden on the inhabitants. This study provided the skin profiles of healthy Cameroonians in different body sites and compared them to healthy Japanese participants. The skin microbiome of Cameroonians was distinguishable from that of Japanese in all skin sites examined in this study. For example, Micrococcus was predominantly found in skin samples of Cameroonians but mostly absent in Japanese skin samples. Instead, the relative abundance of Cutibacterium species was significantly higher in healthy Japanese. Principal coordinate analysis of beta diversity showed that the skin microbiome of Cameroonians formed different clusters from Japanese, suggesting a substantial difference in the microbiome profiles between participants of both countries. In addition, the alpha diversity in skin microbes was higher in Cameroonians than Japanese participants. These data may offer insights into the determinant factors responsible for the distinctness of the skin microbiome of people living in Central Africa and Asia.
Funder
Kanazawa University Sakigake Project
Overseas Research Support for Young Scientists
International Research Training Program, National Institute on Minority Health and Health Disparities
Global Infectious Disease Research Training, Fogarty International Center, National Institutes of Health
Centers of Biomedical Research Excellence, National Institute of General Medical Sciences, NIH
National Institute of Allergy and Infectious Diseases, NIH
Career Development Award from the American Association of University Women Hawaii Branch
AMED-PRIME, AMED
Japan Society for the Promotion of Science Kakenhi
Japan Science and Technology Corporation
Publisher
Springer Science and Business Media LLC
Cited by
13 articles.
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