Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-017-00515-y.pdf
Reference25 articles.
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2. Ligon, B., Yang, J., Morin, S. B., Ruberti, M. F. & Steer, M. L. Regulation of pancreatic islet cell survival and replication by gamma-aminobutyric acid. Diabetologia 50, 764–773 (2007).
3. Soltani, N. et al. GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes. Proc Natl Acad Sci USA 108, 11692–11697 (2011).
4. Tian, J. et al. GABA regulates both the survival and replication of human ß-cells. Diabetes 62, 3760–3765, doi: 10.2337/db13-0931 (2013).
5. Prud’homme, G. J. et al. GABA Protects Human Islet Cells Against the Deleterious Effects of Immunosuppressive Drugs and Exerts Immunoinhibitory Effects Alone. Transplantation. doi: 10.1097/TP.0b013e31829c24be (2013).
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