Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility

Author:

Douthwaite Julie A.,Brown Christopher A.,Ferdinand John R.,Sharma Rahul,Elliott Jane,Taylor Molly A.,Malintan Nancy T.,Duvoisin Hannah,Hill Thomas,Delpuech Oona,Orton Alexandra L.,Pitt Haidee,Kuenzi Fred,Fish Simon,Nicholls David J.,Cuthbert Anna,Richards Ian,Ratcliffe Giles,Upadhyay Abhishek,Marklew Abigail,Hewitt Craig,Ross-Thriepland Douglas,Brankin Christopher,Chodorge Matthieu,Browne Gareth,Mander Palwinder K.,DeWildt Ruud M.,Weaver Shane,Smee Penny A.,van Kempen Joost,Bartlett Jon G.,Allen Paula M.,Koppe Emma L.,Ashby Charlotte A.,Phipps Julian D.,Mehta Nalini,Brierley David J.,Tew David G.,Leveridge Melanie V.,Baddeley Stuart M.,Goodfellow Ian G.,Green Clive,Abell Chris,Neely Andy,Waddell Ian,Rees Steve,Maxwell Patrick H.,Pangalos Menelas N.,Howes Rob,Clark Roger

Abstract

AbstractOn 11th March 2020, the UK government announced plans for the scaling of COVID-19 testing, and on 27th March 2020 it was announced that a new alliance of private sector and academic collaborative laboratories were being created to generate the testing capacity required. The Cambridge COVID-19 Testing Centre (CCTC) was established during April 2020 through collaboration between AstraZeneca, GlaxoSmithKline, and the University of Cambridge, with Charles River Laboratories joining the collaboration at the end of July 2020. The CCTC lab operation focussed on the optimised use of automation, introduction of novel technologies and process modelling to enable a testing capacity of 22,000 tests per day. Here we describe the optimisation of the laboratory process through the continued exploitation of internal performance metrics, while introducing new technologies including the Heat Inactivation of clinical samples upon receipt into the laboratory and a Direct to PCR protocol that removed the requirement for the RNA extraction step. We anticipate that these methods will have value in driving continued efficiency and effectiveness within all large scale viral diagnostic testing laboratories.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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