Impact of porcine cytomegalovirus on long-term orthotopic cardiac xenotransplant survival

Author:

Denner Joachim,Längin Matthias,Reichart Bruno,Krüger Luise,Fiebig Uwe,Mokelke Maren,Radan Julia,Mayr Tanja,Milusev Anastasia,Luther Fabian,Sorvillo Nicoletta,Rieben Robert,Brenner Paolo,Walz Christoph,Wolf Eckhard,Roshani Berit,Stahl-Hennig Christiane,Abicht Jan-Michael

Abstract

AbstractXenotransplantation using pig organs has achieved survival times up to 195 days in pig orthotopic heart transplantation into baboons. Here we demonstrate that in addition to an improved immunosuppressive regimen, non-ischaemic preservation with continuous perfusion and control of post-transplantation growth of the transplant, prevention of transmission of the porcine cytomegalovirus (PCMV) plays an important role in achieving long survival times. For the first time we demonstrate that PCMV transmission in orthotopic pig heart xenotransplantation was associated with a reduced survival time of the transplant and increased levels of IL-6 and TNFα were found in the transplanted baboon. Furthermore, high levels of tPA-PAI-1 complexes were found, suggesting a complete loss of the pro-fibrinolytic properties of the endothelial cells. These data show that PCMV has an important impact on transplant survival and call for elimination of PCMV from donor pigs.

Funder

Projekt DEAL

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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