Rational selection of morphological phenotypic traits to extract essential similarities in chemical perturbation in the ergosterol pathway
Author:
Funder
Japan Society for the Promotion of Science
Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41598-024-67634-1.pdf
Reference33 articles.
1. Jordá, T. & Puig, S. Regulation of ergosterol biosynthesis in Saccharomyces cerevisiae. Genes 11, 795. https://doi.org/10.3390/genes11070795 (2020).
2. Johnston, E. J., Moses, T. & Rosser, S. J. The wide-ranging phenotypes of ergosterol biosynthesis mutants, and implications for microbial cell factories. Yeast 37, 27–44. https://doi.org/10.1002/yea.3452 (2020).
3. OMeara, T. R. et al. Global analysis of fungal morphology exposes mechanisms of host cell escape. Nat. Commun. 6, 6741. https://doi.org/10.1038/ncomms7741 (2015).
4. Mukhopadhyay, K. et al. Membrane sphingolipid-ergosterol interactions are important determinants of multidrug re-sistance in Candida albicans. Antimicrob. Agents Chemother. 48, 1778–1787. https://doi.org/10.1128/aac.48.5.1778-1787.2004 (2004).
5. Liu, G., Chen, Y., Færgeman, N. J. & Nielsen, J. Elimination of the last reactions in ergosterol biosynthesis alters the resistance of Saccharomyces cerevisiae to multiple stresses. FEMS Yeast Res. 17, fox063. https://doi.org/10.1093/femsyr/fox063 (2017).
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