Author:
Li Meng,Tian Wei,Yu Yangxiao,Zhang Yao,Zhang Boyu,Xu Jianmei,Wang Jiannan
Abstract
AbstractRegenerated silk fibroin (RSF) and regenerated sericin (RSS) have attracted much attention for tissue engineering due to excellent biocompatibility and controllable degradation. However, pure RSF films prepared by existing methods are brittle, which limits applications in the field of high-strength and/or flexible tissues (e.g. cornea, periosteum and dura). A series of RSF/RSS composite films were developed from solutions prepared by dissolving silks with different degumming rates. The molecular conformation, crystalline structure and tensile properties of the films and the effect of sericin content on the structure and properties were investigated. Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction results revealed more β-sheets in films prepared by boiling water degumming than in Na2CO3-degummed RSFCfilm. Analysis of mechanical properties showed that the breaking strength (3.56 MPa) and elongation (50.51%) of boiling water-degummed RSF/RSS film were significantly increased compared with RSFCfilm (2.60 MPa and 32.31%), and the flexibility of films could be further improved by appropriately reducing the degumming rate.
Funder
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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