Author:
Ianniello Carlotta,Moy Linda,Fogarty Justin,Schnabel Freya,Adams Sylvia,Axelrod Deborah,Axel Leon,Brown Ryan,Madelin Guillaume
Abstract
AbstractThe purpose of this work was to develop a novel method to disentangle the intra- and extracellular components of the total sodium concentration (TSC) in breast cancer from a combination of proton ($$^{1}$$
1
H) and sodium ($$^{23}\hbox {Na}$$
23
Na
) magnetic resonance imaging (MRI) measurements. To do so, TSC is expressed as function of the intracellular sodium concentration ($$\hbox {C}_{\text {IC}}$$
C
IC
), extracellular volume fraction (ECV) and the water fraction (WF) based on a three-compartment model of the tissue. TSC is measured from $$^{23}\hbox {Na}$$
23
Na
MRI, ECV is calculated from baseline and post-contrast $$^{1}$$
1
H $$\hbox {T}_{{1}}$$
T
1
maps, while WF is measured with a $$^{1}$$
1
H chemical shift technique. $$\hbox {C}_{\text {IC}}$$
C
IC
is then extrapolated from the model. Proof-of-concept was demonstrated in three healthy subjects and two patients with triple negative breast cancer. In both patients, TSC was two to threefold higher in the tumor than in normal tissue. This alteration mainly resulted from increased $$\hbox {C}_{\text {IC}}$$
C
IC
($$\sim$$
∼
30 mM), which was $$\sim$$
∼
130% greater than in healthy conditions (10–15 mM) while the ECV was within the expected range of physiological values (0.2–0.25). Multinuclear MRI shows promise for disentangling $$\hbox {C}_{\text {IC}}$$
C
IC
and ECV by taking advantage of complementary $$^{1}$$
1
H and $$^{23}\hbox {Na}$$
23
Na
measurements.
Funder
National Cancer Institute
National Institute of Biomedical Imaging and Bioengineering
National Institute on Aging
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Neurological Disorders and Stroke
Publisher
Springer Science and Business Media LLC
Reference63 articles.
1. Azamjah, N., Soltan-Zadeh, Y. & Zayeri, F. Global trend of breast cancer mortality rate: a 25-year study. APJCP 20, 2015 (2019).
2. Bray, F. et al. Global cancer statistics 2018: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68, 394–424 (2018).
3. Shahid, H., Wiedenhoefer, J. F., Dornbluth, C., Otto, P. & Kist, K. A. An overview of breast MRI. Appl. Radiol. 45, 7 (2016).
4. Partridge, S. C. & Amornsiripanitch, N. The role of DWI in the assessment of breast lesions. TMRI 26, 201 (2017).
5. Jacobs, M. A. et al. Multiparametric and multinuclear magnetic resonance imaging of human breast cancer: current applications. Technol. Cancer Res. Treat. 3, 543–50. https://doi.org/10.1177/153303460400300603 (2004).
Cited by
18 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献