Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1

Author:

Jha Sawan KumarORCID,Rauniyar Khushbu,Karpanen Terhi,Leppänen Veli-Matti,Brouillard PascalORCID,Vikkula Miikka,Alitalo Kari,Jeltsch MichaelORCID

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference38 articles.

1. Alitalo, K. The lymphatic vasculature in disease. Nature Medicine 17, 1371–1380 (2011).

2. Krebs, R. & Jeltsch, M. The lymphangiogenic growth factors VEGF-C and VEGF-D Part 1: Basic principles and embryonic development. LymphForsch 17, 30–37 (2013).

3. Krebs, R. & Jeltsch, M. The lymphangiogenic growth factors VEGF-C and VEGF-D Part 2: The role of lymphangiogenic growth factors VEGF-C and VEGF-D in lymphatic disorders. LymphForsch 17, 96–104 (2013).

4. Joukov, V. et al. Proteolytic processing regulates receptor specificity and activity of VEGF-C. The EMBO Journal 16, 3898–3911 (1997).

5. Villefranc, J. A. et al. A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development. Development 140, 1497–1506 (2013).

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