Abstract
AbstractThe striatum integrates dense neuromodulatory inputs from many brain regions to coordinate complex behaviors. This integration relies on the coordinated responses from distinct striatal cell types. While previous studies have characterized the cellular and molecular composition of the striatum using single-cell RNA-sequencing at distinct developmental timepoints, the molecular changes spanning embryonic through postnatal development at the single-cell level have not been examined. Here, we combine published mouse striatal single-cell datasets from both embryonic and postnatal timepoints to analyze the developmental trajectory patterns and transcription factor regulatory networks within striatal cell types. Using this integrated dataset, we found that dopamine receptor-1 expressing spiny projection neurons have an extended period of transcriptional dynamics and greater transcriptional complexity over postnatal development compared to dopamine receptor-2 expressing neurons. Moreover, we found the transcription factor, FOXP1, exerts indirect changes to oligodendrocytes. These data can be accessed and further analyzed through an interactive website (https://mouse-striatal-dev.cells.ucsc.edu).
Funder
U.S. Department of Health and Human Services | NIH | National Institute of Mental Health
U.S. Department of Health and Human Services | NIH | National Institute of Neurological Disorders and Stroke
U.S. Department of Health and Human Services | NIH | National Human Genome Research Institute
Simons Foundation
James S. McDonnell Foundation
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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