Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-017-13102-y.pdf
Reference26 articles.
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3. Charlton, M. R. et al. Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States. Gastroenterology. 141, 1249–1253 (2011).
4. Fiorucci, S. & Distrutti, E. Bile acid-activated receptors, intestinal microbiota and the treatment of metabolic disorders. Trends Mol Med. 21, 702–714 (2015).
5. Kawamata, Y. et al. A G protein-coupled receptor responsive to bile acids. J Biol Chem. 278, 9435–9440 (2003).
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