Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout
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Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-017-00706-7.pdf
Reference26 articles.
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2. Neogi, T. Clinical practice. Gout. N Engl J Med 364, 443–452, doi: 10.1056/NEJMcp1001124 (2011).
3. Kratzer, J. T. et al. Evolutionary history and metabolic insights of ancient mammalian uricases. Proc. Natl. Acad. Sci. USA 111, 3763–3768, doi: 10.1073/pnas.1320393111 (2014).
4. Tan, P. K., Farrar, J. E., Gaucher, E. A. & Miner, J. N. Coevolution of URAT1 and uricase during primate evolution: implications for serum urate homeostasis and gout. Mol. Biol. Evol. 33, 2193–200, doi: 10.1093/molbev/msw116. (2016).
5. Levinson, D. J. & Sorensen, L. B. Renal handling of uric acid in normal and gouty subject: evidence for a 4-component system. Ann. Rheum. Dis 39, 173–179, doi: 10.1136/ard.39.2.173 (1980).
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