Sauchinone controls hepatic cholesterol homeostasis by the negative regulation of PCSK9 transcriptional network-Reference-Cited by-同舟云学术

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Sauchinone controls hepatic cholesterol homeostasis by the negative regulation of PCSK9 transcriptional network

Published:2018-04-30 Issue:1 Volume:8 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Chae Hee-Sung,You Byoung Hoon,Kim Dong-Yeop,Lee Hankyu,Ko Hyuk Wan,Ko Hyun-Jeong,Choi Young Hee,Choi Sun Shim,Chin Young-Won

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-018-24935-6.pdf

Reference57 articles.

1. Horton, J. D., Goldstein, J. L. & Brown, M. S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109, 1125–1131 (2002).

2. Brown, M. S. & Goldstein, J. L. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 89, 331–340 (1997).

3. Browning, J. D. & Horton, J. D. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest. 114, 147–152 13 (2004).

4. Dubuc, G. et al. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. Arterioscler Thromb Vasc Biol. 24, 1454–1459 (2004).

5. Sharpe, L. J. & Brown, A. J. Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR). J Biol Chem. 288, 18707–18715 (2013).

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