Author:
Hirata Yuki,Oishi Akio,Maekawa Yuki,Tsuiki Eiko,Machida Akira,Kurihara Junko,Kitaoka Takashi
Abstract
AbstractThe appropriate timing of treatment cessation after treat and extend (TAE) regimen for age-related macular degeneration has not been established. This study aimed to investigate the incidence and risk factors of recurrence after cessation of the TAE regimen. We included patients who received and discontinued the TAE regimen, after extension of the treatment interval to ≥ 12 weeks. Forty-nine patients were included in the study. The estimated recurrence rates were 33% at 1 year and 48% at 2 years after treatment cessation, respectively. Good visual acuity at cessation and a large number of injections in the 6 months before cessation were significant risk factors. Higher chances of recurrence were associated with < 0.1 logarithm of the minimum angle of resolution (logMAR) at cessation (P < 0.002). Meanwhile, five patients with visual acuity ≥ 1.0 logMAR at cessation did not show recurrence. Among the 25 recurrences, two lines of vision loss were noted in only two cases after resumed treatment. This study confirmed the importance of the number of injections in reducing recurrence and the association between visual acuity and recurrence. Recurrence is generally well-controlled with resumed treatment.
Funder
Bayer Pharmaceutical, Japan
Novartis Pharma, Japan
Senju Pharmaceutical, Japan
Santen Pharmaceutical, Japan
Chugai Pharmaceutical, Japan
Japan Society for the Promotion of Science
ALCON JAPAN, Japan
Kowa Pharmaceutical, Japan
Publisher
Springer Science and Business Media LLC
Cited by
3 articles.
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