Author:
López-Domínguez Lorena,Bassani Diego G.,Bourdon Celine,Massara Paraskevi,Santos Iná S.,Matijasevich Alicia,Barros Aluísio. J. D.,Comelli Elena M.,Bandsma Robert H. J.
Abstract
AbstractChild growth patterns assessment is critical to design public health interventions. However, current analytical approaches may overlook population heterogeneity. To overcome this limitation, we developed a growth trajectories clustering pipeline that incorporates a shape-respecting distance, baseline centering (i.e., birth-size normalized trajectories) and Gestational Age (GA)-correction to characterize shape-based child growth patterns. We used data from 3945 children (461 preterm) in the 2004 Pelotas Birth Cohort with at least 3 measurements between birth (included) and 11 years of age. Sex-adjusted weight-, length/height- and body mass index-for-age z-scores were derived at birth, 3 months, and at 1, 2, 4, 6 and 11 years of age (INTERGROWTH-21st and WHO growth standards). Growth trajectories clustering was conducted for each anthropometric index using k-means and a shape-respecting distance, accounting or not for birth size and/or GA-correction. We identified 3 trajectory patterns for each anthropometric index: increasing (High), stable (Middle) and decreasing (Low). Baseline centering resulted in pattern classification that considered early life growth traits. GA-correction increased the intercepts of preterm-born children trajectories, impacting their pattern classification. Incorporating shape-based clustering, baseline centering and GA-correction in growth patterns analysis improves the identification of subgroups meaningful for public health interventions.
Funder
Consejo Nacional de Ciencia y Tecnología
Peterborough K. M. Hunter Charitable Foundation,Canada
Connaught International Scholarship
Onassis Foundation
Associação Brasileira de Saúde Coletiva
Wellcome Trust
World Health Organization
National Support Program for Centers of Excellence, Brazil
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Ministério da Saúde
Children's Pastorate, Brazil
Joannah and Brian Lawson Centre for Child Nutrition, Faculty of Medicine, University of Toronto
Publisher
Springer Science and Business Media LLC
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献