Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpoints
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-017-07498-w.pdf
Reference45 articles.
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2. Rothwell, N. J., Stock, M. J. & Tyzbir, R. S. Energy balance and mitochondrial function in liver and brown fat of rats fed “cafeteria” diets of varying protein content. J Nutr 112, 1663–1672 (1982).
3. Rothwell, N. J. & Stock, M. J. Influence of carbohydrate and fat intake on diet-induced thermogenesis and brown fat activity in rats fed low protein diets. J Nutr 117, 1721–1726 (1987).
4. Laeger, T. et al. Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2. Cell reports 16, 707–716 (2016).
5. Laeger, T. et al. FGF21 is an endocrine signal of protein restriction. J Clin Invest 124, 3913–3922 (2014).
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