Author:
Diaz-Marin Roberto,Crespo-Garcia Sergio,Wilson Ariel M.,Buscarlet Manuel,Dejda Agnieszka,Fournier Frédérik,Juneau Rachel,Alquier Thierry,Sapieha Przemyslaw
Abstract
AbstractThe beneficial effects of brown adipose tissue (BAT) on obesity and associated metabolic diseases are mediated through its capacity to dissipate energy as heat. While immune cells, such as tissue-resident macrophages, are known to influence adipose tissue homeostasis, relatively little is known about their contribution to BAT function. Here we report that neuropilin-1 (NRP1), a multiligand single-pass transmembrane receptor, is highly expressed in BAT-resident macrophages. During diet-induced obesity (DIO), myeloid-resident NRP1 influences interscapular BAT mass, and consequently vascular morphology, innervation density and ultimately core body temperature during cold exposure. Thus, NRP1-expressing myeloid cells contribute to the BAT homeostasis and potentially its thermogenic function in DIO.
Funder
Fonds de Recherche du Département d’Ophtalmologie de l’Université de Montréal
Fonds de Recherche du Québec - Santé
Canadian Institutes of Health Research
Diabetes Canada
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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