Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis-Reference-Cited by-同舟云学术

Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis

Published:2019-02-26 Issue:1 Volume:9 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Okura Toshiaki,Ohkawara Bisei^ORCID,Takegami Yasuhiko,Ito Mikako,Masuda Akio,Seki Taisuke,Ishiguro Naoki,Ohno Kinji^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-019-39393-x.pdf

Reference51 articles.

1. Bijlsma, J. W., Berenbaum, F. & Lafeber, F. P. Osteoarthritis: an update with relevance for clinical practice. Lancet 377, 2115–2126, https://doi.org/10.1016/S0140-6736(11)60243-2 (2011).

2. Heinegård, D. & Saxne, T. The role of the cartilage matrix in osteoarthritis. Nat. Rev. Rheumatol. 7, 50–56, https://doi.org/10.1038/nrrheum.2010.198 (2011).

3. Kannu, P., Bateman, J. F., Belluoccio, D., Fosang, A. J. & Savarirayan, R. Employing molecular genetics of chondrodysplasias to inform the study of osteoarthritis. Arthritis Rheum. 60, 325–334, https://doi.org/10.1002/art.24251 (2009).

4. Clevers, H. & Nusse, R. Wnt/β-catenin signaling and disease. Cell 149, 1192–1205, https://doi.org/10.1016/j.cell.2012.05.012 (2012).

5. Zhu, M. et al. Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice. J. Bone Miner. Res. 24, 12–21, https://doi.org/10.1359/jbmr.080901 (2009).

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