Abstract
AbstractSerum glypican-4 (GPC4) has been identified as an insulin-sensitizing adipokine serving as a marker for body mass index and insulin resistance in humans. The association of circulating GPC4 with kidney function is to date largely unexplored. Therefore, we aimed to evaluate the association between serum GPC4 and prevalent as well future kidney function in a prospective cohort study. The study included 456 Caucasian coronary angiography patients. After a median follow up period of 3.4 years, data on kidney function was reassessed in all patients. Chronic kidney disease (CKD) was defined by decreased estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 or albuminuria. At baseline, serum GPC4 was significantly associated with decreased eGFR (adjusted odds ratio (OR) per standard deviation = 4.75 [2.66–8.48]; P < 0.001), albuminuria (OR = 1.49 [1.15–1.92]; P = 0.002), and, accordingly, with CKD (OR = 1.75 [1.35–2.26]; P < 0.001). GPC4 levels also significantly and independently predicted the incidence of newly diagnosed decreased eGFR (OR = 2.74 [1.82–4.14]; P < 0.001, albuminuria (OR = 1.58 [1.01–2.46]; P = 0.043, and CKD (OR = 2.16 [1.45–3.23]; P < 0.001). ROC analysis indicated an additional predictive value of GPC4 to a basic prediction model for newly diagnosed CKD and eGFR < 60 mL/min/1.73 m2. Our study, therefore, indicates that high serum GPC4 is associated with decreased prevalent and future kidney function.
Publisher
Springer Science and Business Media LLC
Reference40 articles.
1. Weiner, D. E. et al. Kidney disease as a risk factor for recurrent cardiovascular disease and mortality. Am. J. Kidney Dis. 44, 198–206 (2004).
2. Tonelli, M. et al. Chronic kidney disease and mortality risk: A systematic review. J. Am. Soc. Nephrol. 17, 2034–2047 (2006).
3. Carmena, R., Ascaso, J. F. & Redon, J. Chronic kidney disease as a cardiovascular risk factor. J. Hypertens. 38, 2110–2121 (2020).
4. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 3, 1–150 (2013).
5. Steubl, D. et al. Plasma uromodulin correlates with kidney function and identifies early stages in chronic kidney disease patients. Med. (United States) 95, 1 (2016).
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