Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-019-43518-7.pdf
Reference54 articles.
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3. Luo, J. et al. LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption. Nat Med 22, 539–546, https://doi.org/10.1038/nm.4076 (2016).
4. Manolagas, S. C. & Jilka, R. L. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 332, 305–311, https://doi.org/10.1056/NEJM199502023320506 (1995).
5. Hendrickx, G., Boudin, E. & Van Hul, W. A look behind the scenes: the risk and pathogenesis of primary osteoporosis. Nat Rev Rheumatol 11, 462–474, https://doi.org/10.1038/nrrheum.2015.48 (2015).
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