Carbenoxolone-mediated cytotoxicity inhibits Vaccinia virus replication in a human keratinocyte cell line
Author:
Funder
Biotechnology and Biological Sciences Research Council
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-018-34732-w.pdf
Reference21 articles.
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2. Abrahao, J. S. et al. Outbreak of severe zoonotic vaccinia virus infection, Southeastern Brazil. Emerg Infect Dis 21, 695–698, https://doi.org/10.3201/eid2104.140351 (2015).
3. Endong, L. et al. The gap-junction inhibitor carbenoxolone suppresses the differentiation of Th17 cells through inhibition of IL-23 expression in antigen presenting cells. J Neuroimmunol 240–241, 58–64, https://doi.org/10.1016/j.jneuroim.2011.09.012 (2011).
4. Li, W., Li, J., Sama, A. E. & Wang, H. Carbenoxolone blocks endotoxin-induced protein kinase R (PKR) activation and high mobility group box 1 (HMGB1) release. Mol Med 19, 203–211, https://doi.org/10.2119/molmed.2013.00064 (2013).
5. Thakur, P. & Nehru, B. Inhibition of neuroinflammation and mitochondrial dysfunctions by carbenoxolone in the rotenone model of Parkinson’s disease. Mol Neurobiol 51, 209–219, https://doi.org/10.1007/s12035-014-8769-7 (2015).
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