Author:
Kaneko Naoki,Chen Hu,Perugino Cory A.,Maehara Takashi,Munemura Ryusuke,Yokomizo Shiho,Sameshima Junsei,Diefenbach Thomas J.,Premo Katherine R.,Chinju Akira,Miyahara Yuka,Sakamoto Mizuki,Moriyama Masafumi,Stone John H.,Nakamura Seiji,Pillai Shiv
Abstract
AbstractSjögren’s syndrome is a chronic autoimmune disorder whose pathogenesis is poorly understood and that lacks effective therapies. Detailed quantitative and spatial analyses of tissues affected by Sjögren’s syndrome were undertaken, including the quantitation of the frequency of selected cell–cell interactions in the disease milieu. Quantitative analyses of CD4+T cell subsets and of CD8+T cells in the labial salivary glands from untreated patients with primary Sjögren’s syndrome revealed that activated CD8+cytotoxic T cells (CD8+CTLs) were the most prominent T cells in these infiltrates. An accumulation of apoptotic glandular epithelial cells, mainly ductal and acinar cells, was observed, consistent with the impaired salivary secretion often observed in patients with this disease. FasL expressing activated CD8+T cells were seen to accumulate around Fas expressing apoptotic epithelial cells. Quantitative analyses of apoptotic cell types and of conjugates between cytotoxic T cells and epithelial cells undergoing apoptosis suggest that Sjögren’s syndrome is primarily driven by CD8+CTL mediated execution of epithelial cells mainly represented by ductal and acinar cells.
Funder
JSPS KAKENHI
National Institute of Arthritis and Musculoskeletal and Skin Diseases
NIH Autoimmune Centers of Excellence
Publisher
Springer Science and Business Media LLC
Cited by
13 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献