Author:
Cosgarea Raluca,Pollmann Robert,Sharif Jusra,Schmidt Thomas,Stein Ronja,Bodea Aura,Auschill Thorsten,Sculean Anton,Eming Rüdiger,Greene Brandon,Hertl Michael,Arweiler Nicole
Abstract
AbstractOral lichen planus (OLP) is a common, chronic relapsing inflammatory disorder of the mucous membranes, which causes major discomfort. Current treatment includes topical/systemic glucocorticoids, immune modulators and systemic immunosuppressants, which may lead to considerable side-effects. The aim of this study was to determine the clinical and immunological efficacy of photodynamic therapy (PDT) in OLP as an alternative, easy-to-use, safe and non-invasive treatment. Twenty patients with OLP were treated with PDT in a prospective case-controlled pilot-study. PDT was performed on the most extensive oral lesion in 4 sessions (day 1, 3, 7, 14). Peripheral blood and lesional T cells were analysed before (day 1) and after PDT treatment (day 28). PDT led to a statistically significant reduction of clinical parameters (lesion size, ABSIS, Thongprasom-score) and improvement of all evaluated quality-of-life (QOL) items. The clinical improvement was accompanied by a significant decrease of the relative number of CD4+ and CD8+ T cells in mucosal OLP-lesions. Furthermore, CXCL10 plasma levels were decreased and the number of activated peripheral CD4 + CD137+ and CD8 + CD137+ T cells and IL-17-secreting T cells was diminished. PDT treatment in OLP leads to lesion reduction and improvement of QOL, and induces local and systemic anti-inflammatory effects. The study identifies PDT as a novel therapeutic option in OLP.
Publisher
Springer Science and Business Media LLC
Reference82 articles.
1. Lavanya, N., Jayanthi, P., Rao, U. K. & Ranganathan, K. Oral lichen planus: An update on pathogenesis and treatment. Journal of oral and maxillofacial pathology: JOMFP 15, 127–132, https://doi.org/10.4103/0973-029X.84474 (2011).
2. Lodi, G., Carrozzo, M., Furness, S. & Thongprasom, K. Interventions for treating oral lichen planus: a systematic review. The British journal of dermatology 166, 938–947, https://doi.org/10.1111/j.1365-2133.2012.10821.x (2012).
3. Lodi, G. et al. Current controversies in oral lichen planus: report of an international consensus meeting. Part 1. Viral infections and etiopathogenesis. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 100, 40–51, https://doi.org/10.1016/j.tripleo.2004.06.077 (2005).
4. Thornhill, M. H. Immune mechanisms in oral lichen planus. Acta odontologica Scandinavica 59, 174–177 (2001).
5. Aghahosseini, F., Arbabi-Kalati, F., Fashtami, L. A., Fateh, M. & Djavid, G. E. Treatment of oral lichen planus with photodynamic therapy mediated methylene blue: a case report. Medicina oral, patologia oral y cirugia bucal 11, E126–9 (2006).
Cited by
34 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献