Author:
Pelzer Esther Annegret,Stürmer Sophie,Feis Delia-Lisa,Melzer Corina,Schwartz Frank,Scharge Marcel,Eggers Carsten,Tittgemeyer Marc,Timmermann Lars
Abstract
AbstractMost classification approaches for idiopathic Parkinson’s disease subtypes primarily focus on motor and non-motor symptoms. Besides these characteristics, other features, including gender or genetic polymorphism of dopamine receptors are potential factors influencing the disease’s phenotype. By utilizing a kmeans-clustering algorithm we were able to identify three subgroups mainly characterized by gender, DRD2 Taq1A (rs1800497) polymorphism—associated with changes in dopamine signaling in the brain—and disease progression. A subsequent regression analysis of these subgroups further suggests an influence of their characteristics on the daily levodopa dosage, an indicator for medication response. These findings could promote further enhancements in individualized therapies for idiopathic Parkinson’s disease.
Funder
Deutsche Forschungsgemeinschaft
Max Planck Institute for Metabolism Research
Publisher
Springer Science and Business Media LLC
Cited by
5 articles.
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