Author:
Gao Sijia,Calderon Diany Paola
Abstract
AbstractThe righting reflex (RR) is frequently used to assess level of arousal and applied to animal models of a range of neurological disorders. RR produces a binary result that, when positive, is used to infer restoration of consciousness, often without further behavioral corroboration. We find that RR is an unreliable metric for arousal/recovery of consciousness. Instead, cortical activity and motor behavior that accompany RR are a non-binary, superior criterion that accurately calibrates and establishes level of arousal in rodents.
Funder
National Institute of Neurological Disorders and Stroke
Publisher
Springer Science and Business Media LLC
Cited by
25 articles.
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