Author:
Geleijnse Gijs,Chiang RuRu Chun-Ju,Sieswerda Melle,Schuurman Melinda,Lee K. C.,van Soest Johan,Dekker Andre,Lee Wen-Chung,Verbeek Xander A. A. M.
Abstract
AbstractThe difference in incidence of oral cavity cancer (OCC) between Taiwan and the Netherlands is striking. Different risk factors and treatment expertise may result in survival differences between the two countries. However due to regulatory restrictions, patient-level analyses of combined data from the Netherlands and Taiwan are infeasible. We implemented a software infrastructure for federated analyses on data from multiple organisations. We included 41,633 patients with single-tumour OCC between 2004 and 2016, undergoing surgery, from the Taiwan Cancer Registry and Netherlands Cancer Registry. Federated Cox Proportional Hazard was used to analyse associations between patient and tumour characteristics, country, treatment and hospital volume with survival. Five factors showed differential effects on survival of OCC patients in the Netherlands and Taiwan: age at diagnosis, stage, grade, treatment and hospital volume. The risk of death for OCC patients younger than 60 years, with advanced stage, higher grade or receiving adjuvant therapy after surgery was lower in the Netherlands than in Taiwan; but patients older than 70 years, with early stage, lower grade and receiving surgery alone in the Netherlands were at higher risk of death than those in Taiwan. The mortality risk of OCC in Taiwanese patients treated in hospitals with higher hospital volume (≥ 50 surgeries per year) was lower than in Dutch patients. We conducted analyses without exchanging patient-level information, overcoming barriers for sharing privacy sensitive information. The outcomes of patients treated in the Netherlands and Taiwan were slightly different after controlling for other prognostic factors.
Funder
Health Promotion Administration, Ministry of Health and Welfare
Publisher
Springer Science and Business Media LLC
Reference39 articles.
1. Hsu, W.-L., Yu, K. J., Chiang, C.-J., Chen, T.-C. & Wang, C.-P. Head and neck cancer incidence trends in Taiwan, 1980 2014. Int. J. Head Neck Sci. 1, 180–190 (2017).
2. Taiwan Cancer Registry Annual Report 2016. (2016).
3. The Netherlands Cancer Registry. https://www.cijfersoverkanker.nl/?language=en (2019).
4. van Dijk, B. A. C., Brands, M. T., Geurts, S. M. E., Merkx, M. A. W. & Roodenburg, J. L. N. Trends in oral cavity cancer incidence, mortality, survival and treatment in the Netherlands: OCC incidence, mortality, survival and treatment. Int. J. Cancer 139, 574–583 (2016).
5. Liu, S.-Y. et al. Surgical outcomes and prognostic factors of oral cancer associated with betel quid chewing and tobacco smoking in Taiwan. Oral Oncol. 46, 276–282 (2010).
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