Author:
Huang Chien-Cheng,Ho Chung-Han,Chen Yi-Chen,Hsu Chien-Chin,Lin Hung-Jung,Su Shih-Bin,Wang Jhi-Joung,Guo How-Ran
Abstract
Abstract
Carbon monoxide poisoning (COP) may cause injuries to the central nervous and endocrine systems, which might increase the risk of developing hypothyroidism. We wanted to evaluate the association between COP and the risk of developing hypothyroidism because epidemiological data on this potential association are limited. We conducted a nationwide population-based cohort study using the Nationwide Poisoning Database and identified 24,328 COP subjects diagnosed between 1999 and 2012. By matching the index date and age, we selected 72,984 non-COP subjects for comparison. Subjects with thyroid diseases and malignancy before 1999 were excluded. We followed up the two groups of subjects until 2013 and compared the risk of developing hypothyroidism. COP subjects had a significantly higher risk for hypothyroidism than non-COP subjects (adjusted hazard ratio [AHR]: 3.8; 95% confidence interval [CI]: 3.2–4.7) after adjusting for age, sex, underlying comorbidities, and monthly income, and the AHR was particular higher in subjects with diabetes mellitus, hyperlipidemia, and mental disorder. The increased risk was highest in the first month after COP (AHR: 41.0; 95% CI: 5.4–310.6), and the impact remained significant even after 4 years. In conclusion, COP was associated with an increased risk for hypothyroidism. Further studies regarding the underlying mechanisms are warranted.
Publisher
Springer Science and Business Media LLC
Reference35 articles.
1. Buckley, N. A., Juurlink, D. N., Isbister, G., Bennett, M. H. & Lavonas, E. J. Hyperbaric oxygen for carbon monoxide poisoning. Cochrane Database Syst Rev. 4, CD002041 (2011).
2. Pan, Y. J., Liao, S. C. & Lee, M. B. Suicide by charcoal burning in Taiwan, 1995-2006. J Affect Disord. 120, 254–257 (2010).
3. Ernst, A. & Zibrak, J. D. Carbon monoxide poisoning. N Engl J Med. 339, 1603–1608 (1998).
4. Huang, C. C. et al. Long-term prognosis of patients with carbon monoxide poisoning: a nationwide cohort study. PLoS One. 9, e105503 (2014).
5. Hampson, N. B., Hauff, N. M. & Rudd, R. A. Increased long-term mortality among survivors of acute carbon monoxide poisoning. Crit Care Med. 37, 1941–1947 (2009).
Cited by
11 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献