Identification of a Different Agonist-Binding Site and Activation Mechanism of the Human P2Y1 Receptor

Author:

Li Yang,Yin Can,Liu Pi,Li Dongmei,Lin Jianping

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference59 articles.

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2. Latorraca, N. R., Venkatakrishnan, A. J. & Dror, R. O. GPCR dynamics: Structures in motion. Chem. Rev. 117, 139–155 (2017).

3. Thomsen, W., Frazer, J. & Unett, D. Functional assays for screening GPCR targets. Curr. Opin. Biotechnol. 16, 655–665 (2005).

4. Lappano, R. & Maggiolini, M. G protein-coupled receptors: Novel targets for drug discovery in cancer. Nat. Rev. Drog Discov. 10, 47–60 (2011).

5. Moro, S., Spalluto, G. & Jacobson, K. A. Techniques: Recent developments in computer-aided engineering of GPCR ligands using the human adenosine A 3 receptor as an example. Trends Pharmacol. Sci. 26, 44–51 (2005).

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