The long-term effect of biologics in patients with ulcerative colitis emerging from a large Japanese cohort

Author:

Yokoyama Yuya,Ohta Yuki,Ogasawara Sadahisa,Kato Jun,Arai Ryoko,Koseki Hirotaka,Saito Masaya,Kaneko Tatsuya,Tokunaga Mamoru,Oura Hirotaka,Oike Tsubasa,Imai Yushi,Kanayama Kengo,Akizue Naoki,Kumagai Junichiro,Taida Takashi,Okimoto Kenichiro,Saito Keiko,Ooka Yoshihiko,Matsumura Tomoaki,Nakagawa Tomoo,Arai Makoto,Katsuno Tatsuro,Fukuda Yoshihiro,Kitsukawa Yoshio,Kato Naoya

Abstract

AbstractTo gain a better understanding of the effects of biologics, we evaluated clinical outcomes in patients with moderate to severe exacerbations of ulcerative colitis (UC). This retrospective, multicenter study retrieved the entire clinical courses of UC patients who began treatments between 2004 and 2018. All exacerbations and clinical parameters, including treatment details for exacerbations and both remission and re-exacerbation dates, were identified during the observation period. Two different endpoints, the cumulative incidence rates of surgical resection and re-exacerbation, were evaluated separately in moderate to severe exacerbation events. Among 1401 patients, 1626 exacerbation events were determined according to a partial Mayo score (remission: < 2, mild: 2–4, moderate: 5–7, and severe: > 7). During the observation period, as administration rates of biologics increased, both surgical resection and hospitalization rates decreased, for 959 moderate to severe exacerbation events. We confirmed that biologics significantly reduced the cumulative re-exacerbation rate in moderate to severe exacerbation events during the study period compared with suboptimal therapies (a 0.507-fold decreased risk according to COX regression analysis, P < 0.001). However, they had not enough impact in reducing the cumulative incidence rate of surgical resection in moderate to severe exacerbation events that were corticosteroid-refractory or dependent (a 0.878-fold decreased risk according to COX regression analysis, P = 0.606). Biologics may improve remission duration, but these agents had no significant impact in reducing the risk of surgical resection in moderate to severe active UC.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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