Device Thrombogenicity Emulation: An In Silico Predictor of In Vitro and In Vivo Ventricular Assist Device Thrombogenicity

Author:

Chiu Wei Che,Tran Phat L.,Khalpey Zain,Lee Eric,Woo Yi-Ren,Slepian Marvin J.,Bluestein Danny

Funder

U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference46 articles.

1. FDA. Thoratec HeartMate II LVAS - P060040/S005, http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/DeviceApprovalsandClearances/Recently-ApprovedDevices/ucm201473.htm (2010).

2. FDA. HeartWare Ventricular Assist System - P100047, http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/DeviceApprovalsandClearances/Recently-ApprovedDevices/ucm330838.htm (2012).

3. FDA. HeartMate 3 Left Ventricular Assist System (LVAS) - P160054/S008, https://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/DeviceApprovalsandClearances/Recently-ApprovedDevices/ucm624155.htm (2018).

4. Slepian, M. J. et al. Shear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis. J Biomech 50, 20–25, https://doi.org/10.1016/j.jbiomech.2016.11.016 (2017).

5. Baumann Kreuziger, L. M. Management of anticoagulation and antiplatelet therapy in patients with left ventricular assist devices. J Thromb Thrombolysis 39, 337–344, https://doi.org/10.1007/s11239-014-1162-6 (2015).

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