Incidence of bacterial and fungal infections in Polish pediatric patients with acute lymphoblastic leukemia during the pandemic
-
Published:2023-12-18
Issue:1
Volume:13
Page:
-
ISSN:2045-2322
-
Container-title:Scientific Reports
-
language:en
-
Short-container-title:Sci Rep
Author:
Zawitkowska JoannaORCID, Drabko Katarzyna, Lejman Monika, Kowalczyk Adrian, Czyżewski Krzysztof, Dziedzic Magdalena, Jaremek Kamila, Zalas-Więcek Patrycja, Szmydki-Baran Anna, Hutnik Łukasz, Czogała Wojciech, Balwierz Walentyna, Żak Iwona, Salamonowicz-Bodzioch Małgorzata, Kazanowska Bernarda, Wróbel Grażyna, Frączkiewicz Jowita, Kałwak Krzysztof, Tomaszewska Renata, Szczepański Tomasz, Zając-Spychała Olga, Wachowiak Jacek, Płonowski Marcin, Krawczuk-Rybak Maryna, Królak Aleksandra, Ociepa Tomasz, Urasiński Tomasz, Pierlejewski Filip, Młynarski Wojciech, Urbańska-Rakus Justyna, Machnik Katarzyna, Pająk Sonia, Badowska Wanda, Brzeski Tomasz, Mycko Katarzyna, Mańko-Glińska Hanna, Urbanek-Dądela Agnieszka, Karolczyk Grażyna, Mizia-Malarz Agnieszka, Stolpa Weronika, Skowron-Kandzia Katarzyna, Musiał Jakub, Chaber Radosław, Irga-Jaworska Ninela, Bień Ewa, Styczyński Jan
Abstract
AbstractThe most common complications related to the treatment of childhood acute lymphoblastic leukemia (ALL) are infections. The aim of the study was to analyze the incidence and mortality rates among pediatric patients with ALL who were treated in 17 Polish pediatric hematology centers in 2020–2021 during the pandemic. Additionally, we compared these results with those of our previous study, which we conducted in the years 2012–2017. The retrospective analysis included 460 patients aged 1–18 years with newly diagnosed ALL. In our study, 361/460 (78.5%) children were reported to have microbiologically documented bacterial infections during chemotherapy. Ten patients (2.8%) died due to sepsis. Fungal infections were reported in 99 children (21.5%), of whom five (5.1%) died due to the infection. We especially observed an increase in bacterial infections during the pandemic period compared to the previous study. The directions of our actions should be to consider antibiotic prophylaxis, shorten the duration of hospitalization, and educate parents and medical staff about complications (mainly infections) during anticancer therapy. It is necessary to continue clinical studies evaluating infection prophylaxis to improve outcomes in childhood ALL patients.
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Reference17 articles.
1. Yeoh, D. K. et al. Invasive fungal disease in children with acute myeloid leukaemia: An Australian multicentre 10-year review. Pediatr. Blood Cancer 68(11), e29275. https://doi.org/10.1002/pbc.29275 (2021). 2. Hough, R. & Vora, A. Crisis management in the treatment of childhood acute lymphoblastic leukemia: Putting right what can go wrong (emergency complications of disease and treatment). Hematol. Am. Soc. Hematol. Educ. Program. 8, 251–258. https://doi.org/10.1182/asheducation-2017.1.251 (2017). 3. Villeneuve, S. & Aftandilian, C. Neutropenia and infection prophylaxis in childhood cancer. Curr. Oncol. Rep 24, 671–686. https://doi.org/10.1007/s11912-022-01192-5 (2022). 4. Inaba, H. et al. Infection-related complications during treatment for childhood acute lymphoblastic leukemia. Ann. Oncol. 1(2(82)), 386–392. https://doi.org/10.1093/annonc/mdw557 (2017). 5. Sezgin Evim, M. et al. Evaluation of central venous catheter-related complications in pediatric acute leukemia patients: Single center experience. J. Pediatr. Hematol. Oncol. 1(451), e92–e96. https://doi.org/10.1097/MPH.0000000000002500 (2023).
|
|