Author:
Tanaka Yuki,Wada Hiroshi,Goto Risa,Osada Toshihiro,Yamamura Keisuke,Fukaya Satoshi,Shimizu Atsushi,Okubo Mitsuru,Minamiguchi Kazuhisa,Ikizawa Koichi,Sasaki Eiji,Utsugi Teruhiro
Abstract
AbstractCancer peptide vaccines are a promising cancer immunotherapy that can induce cancer-specific cytotoxic T lymphocytes (CTLs) in tumors. However, recent clinical trials of cancer vaccines have revealed that the efficacy of the vaccines is limited. Targeting single antigens and vaccination with short peptides are partly the cause of the poor clinical outcomes. We synthesized a novel multi-epitope long peptide, TAS0314, which induced multiple epitope-specific CTLs in HLA knock-in mice. It also showed superior epitope-specific CTL induction and antitumor activity. We also established a combination treatment model of vaccination with PD-1/PD-L1 blockade in HLA-A*2402 knock-in mice, and it showed a synergistic antitumor effect with TAS0314. Thus, our data indicated that TAS0314 treatment, especially in combination with PD-1/PD-L1 blockade, is a promising therapeutic candidate for cancer immunotherapy.
Publisher
Springer Science and Business Media LLC
Cited by
18 articles.
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