Telomerase gene expression bioassays indicate metabolic activation of genotoxic lower chlorinated polychlorinated biphenyls
Author:
Funder
RWTH Aachen University
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-018-35043-w.pdf
Reference45 articles.
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2. Lauby-Secretan, B. et al. Carcinogenicity of polychlorinated biphenyls and polybrominated biphenyls. Lancet Oncol 14, 287–288, https://doi.org/10.1016/S1470-2045(13)70104-9 (2013).
3. Lauby-Secretan, B. et al. Use of mechanistic data in the IARC evaluations of the carcinogenicity of polychlorinated biphenyls and related compounds. Environmental science and pollution research international 23, 2220–2229, https://doi.org/10.1007/s11356-015-4829-4 (2016).
4. Lu, Z., Kania-Korwel, I., Lehmler, H. J. & Wong, C. S. Stereoselective formation of mono- and dihydroxylated polychlorinated biphenyls by rat cytochrome P450 2B1. Environmental science & technology 47, 12184–12192, https://doi.org/10.1021/es402838f (2013).
5. Warner, N. A., Martin, J. W. & Wong, C. S. Chiral polychlorinated biphenyls are biotransformed enantioselectively by mammalian cytochrome P-450 isozymes to form hydroxylated metabolites. Environmental science & technology 43, 114–121 (2009).
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