Author:
Masiewicz Elzbieta,Ashcroft George P.,Boddie David,Dundas Sinclair R.,Kruk Danuta,Broche Lionel M.
Abstract
AbstractThis work explores what Fast Field-Cycling Nuclear Magnetic Resonance (FFC-NMR) relaxometry brings for the study of sarcoma to guide future in vivo analyses of patients. We present the results of an ex vivo pilot study involving 10 cases of biopsy-proven sarcoma and we propose a quantitative method to analyse 1H NMR relaxation dispersion profiles based on a model-free approach describing the main dynamical processes in the tissues and assessing the amplitude of the Quadrupole Relaxation Enhancement effects due to 14N. This approach showed five distinct groups of dispersion profiles indicating five discrete categories of sarcoma, with differences attributable to microstructure and rigidity. Data from tissues surrounding sarcomas indicated very significant variations with the proximity to tumour, which may be attributed to varying water content but also to tissue remodelling processes due to the sarcoma. This pilot study illustrates the potential of FFC relaxometry for the detection and characterisation of sarcoma.
Funder
European Cooperation in Science and Technology
Horizon 2020 Framework Programme
Publisher
Springer Science and Business Media LLC
Reference57 articles.
1. Canet, D. Introduction: General theory of nuclear relaxation. in Advances in Inorganic Chemistry Vol. 57 3–40 (Academic Press, New York, 2005).
2. Kowalewski, J. & Maler, L. Nuclear Spin Relaxation in Liquids : Theory, Experiments, and Applications, 2nd Edn. (CRC Press, London, 2017).
3. Dong, R. Y. NMR relaxation rates. in Encyclopedia of Spectroscopy and Spectrometry (ed. Lindon, J. C.) 1568–1575 (Elsevier, London, 1999).
4. Wahsner, J., Gale, E. M., Rodríguez-Rodríguez, A. & Caravan, P. Chemistry of MRI contrast agents: Current challenges and new frontiers. Chem. Rev. 119, 957–1057 (2019).
5. Merbach, A., Helm, L. & Tóth, É. The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging. (Wiley, New York, 2013).
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