Author:
Stopková Romana,Matějková Tereza,Dodoková Alica,Talacko Pavel,Zacek Petr,Sedlacek Radislav,Piálek Jaroslav,Stopka Pavel
Abstract
AbstractIn most mammals and particularly in mice, chemical communication relies on the detection of ethologically relevant fitness-related cues from other individuals. In mice, urine is the primary source of these signals, so we employed proteomics and metabolomics to identify key components of chemical signalling. We show that there is a correspondence between urinary volatiles and proteins in the representation of genetic background, sex and environment in two house mouse subspecies Mus musculus musculus and M. m. domesticus. We found that environment has a strong influence upon proteomic and metabolomic variation and that volatile mixtures better represent males while females have surprisingly more sex-biased proteins. Using machine learning and combined-omics techniques, we identified mixtures of metabolites and proteins that are associated with biological features.
Funder
Horizon 2020 Framework Programme
Univerzita Karlova v Praze
Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences
Akademie Věd České Republiky
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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