Targeting cell-derived markers to improve the detection of invisible biological traces for the purpose of genetic-based criminal identification

Author:

Recipon Mathilde,Agniel Rémy,Leroy-Dudal Johanne,Fritz Thibaud,Carreiras Franck,Hermitte Francis,Hubac Sylvain,Gallet Olivier,Kellouche Sabrina

Abstract

AbstractAt a crime scene, investigators are faced with a multitude of traces. Among them, biological traces are of primary interest for the rapid genetic-based identification of individuals. “Touch DNA” consists of invisible biological traces left by the simple contact of a person’s skin with objects. To date, these traces remain undetectable with the current methods available in the field. This study proposes a proof-of-concept for the original detection of touch DNA by targeting cell-derived fragments in addition to DNA. More specifically, adhesive-structure proteins (laminin, keratin) as well as carbohydrate patterns (mannose, galactose) have been detected with keratinocyte cells derived from a skin and fingermark touch-DNA model over two months in outdoor conditions. Better still, this combinatory detection strategy is compatible with DNA profiling. This proof-of-concept work paves the way for the optimization of tools that can detect touch DNA, which remains a real challenge in helping investigators and the delivery of justice.

Funder

Progamme initiative d’excellence Paris Seine Gendtrack

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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