Author:
Buczyńska Angelika,Sidorkiewicz Iwona,Rogucki Mariusz,Siewko Katarzyna,Adamska Agnieszka,Kościuszko Maria,Maliszewska Katarzyna,Kozłowska Gabryela,Szumowski Piotr,Myśliwiec Janusz,Dzięcioł Janusz,Krętowski Adam,Popławska-Kita Anna
Abstract
AbstractIt is hypothesized that the oxidative stress level in thyroid cancer patients is additionally upregulated by radioactive iodine (RAI) treatment, that may exert an important impact on future health concerns. In our study, we evaluated the oxidative stress level changes using the measurement of malondialdehyde (MDA) concentration in patients with differentiated thyroid cancer (DTC) undergoing RAI treatment. Considering the results obtained in the study group, the serum levels of MDA in DTC patients were significantly higher compared to the healthy subjects (p < 0.05). The MDA concentration was significantly higher on the third day after RAI (p < 0.001) and significantly lower one year after RAI (p < 0.05) in DTC patients compared to the baseline concentration. Moreover, the redox stabilization after RAI treatment in patients with DTC during a year-long observation was demonstrated. Accordingly, an increased oxidative stress impact on the related biochemical parameters reflecting the health conditions of the DTC patients was determined. Our study showed that increased oxidative stress reflected by MDA measurements in DTC patients is further enhanced by RAI, but this effect is no longer observed one year after the therapy.
Funder
Internal financing of the Medical University of Bialystok
Publisher
Springer Science and Business Media LLC
Cited by
19 articles.
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