Author:
Correa-Fiz Florencia,Neila-Ibáñez Carlos,López-Soria Sergio,Napp Sebastian,Martinez Blanca,Sobrevia Laia,Tibble Simon,Aragon Virginia,Migura-Garcia Lourdes
Abstract
AbstractMedicated feed is a common strategy to control the occurrence of Streptococcus suis disease in swine production, but feed additives may constitute an alternative to metaphylaxis. In a farm with post-weaning S. suis disease, the following additives were tested: lysozyme (Lys), medium chain fatty acids plus lysozyme (FA + Lys), FA plus a natural anti-inflammatory (FA + antiinf) and amoxicillin (Amox). During the course of the study, FA + antiinf and Amox groups showed lower prevalence of clinical signs compatible with S. suis disease than the rest of the groups. Piglets from the FA + antiinf group showed high diversity and richness in their nasal and faecal microbiota. Diet supplements did not have major effects on the faecal microbiota, where the genus Mitsuokella was the only differentially present in the FA + Lys group. In the nasal microbiota, piglets from FA + antiinf presented higher differential abundance of a sequence variant from Ruminococcaceae and lower abundance of an unclassified genus from Weeksellaceae. In general, we detected more significant changes in the nasal than in the feacal microbiota, and found that parity of the dams affected the microbiota composition of their offspring, with piglets born to gilts exhibiting lower richness and diversity. Our results suggest that additives could be useful to control post-weaning disease when removing antimicrobials in farms.
Funder
Horizon 2020 Framework Programme
ASN S.L.
Publisher
Springer Science and Business Media LLC
Reference61 articles.
1. Davies, J. & Davies, D. Origins and evolution of antibiotic resistance. Microbiol. Mol. Biol. Rev. 74, 417–433 (2010).
2. Seitz, M., Valentin-Weigand, P. & Willenborg, J. Use of antibiotics and antimicrobial resistance in veterinary medicine as exemplified by the Swine Pathogen Streptococcus suis. Curr. Top. Microbiol. Immunol. 398, 103–121 (2016).
3. Callens, B. et al. Prophylactic and metaphylactic antimicrobial use in Belgian fattening pig herds. Prev. Vet. Med. 106, 53–62 (2012).
4. Cloutier, G. et al. Epidemiology of Streptococcus suis serotype 5 infection in a pig herd with and without clinical disease. Vet. Microbiol. 97, 135–151 (2003).
5. Hopkins, D., Poljak, Z., Farzan, A. & Friendship, R. Factors contributing to mortality during a Streptoccocus suis outbreak in nursery pigs. Can. Vet. J. 59, 623–630 (2018).
Cited by
20 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献