Author:
Hamedifar Haleh,Mirfattahi Mahroo,Khalili Ghomi Minoo,Azizian Homa,Iraji Aida,Noori Milad,Moazzam Ali,Dastyafteh Navid,Nokhbehzaim Ali,Mehrpour Katayoun,Javanshir Shahrzad,Mojtabavi Somayeh,Faramarzi Mohammad Ali,Larijani Bagher,Hajimiri Mir Hamed,Mahdavi Mohammad
Abstract
AbstractRegarding the important role of α-glucosidase enzyme in the management of type 2 diabetes mellitus, the current study was established to design and synthesize aryl-quinoline-4-carbonyl hydrazone bearing different 2-methoxyphenoxyacetamide (11a–o) and the structure of all derivatives was confirmed through various techniques including IR, 1H-NMR, 13C-NMR and elemental analysis. Next, the α-glucosidase inhibitory potentials of all derivatives were evaluated, and all compounds displayed potent inhibition with IC50 values in the range of 26.0 ± 0.8–459.8 ± 1.5 µM as compared to acarbose used as control, except 11f and 11l. Additionally, in silico-induced fit docking and molecular dynamics studies were performed to further investigate the interaction, orientation, and conformation of the newly synthesized compounds over the active site of α-glucosidase.
Publisher
Springer Science and Business Media LLC