Author:
Huang Wan-Chun,Chen Yen-Chou,Wu Chung-Hsuen,Ko Yu
Abstract
AbstractWe aimed to compare the (1) clinical outcomes including composite cardiovascular outcomes, cardiovascular death, and all-cause death, and (2) healthcare costs of using liraglutide and basal insulin as an initial treatment for patients with type 2 diabetes mellitus (T2DM) and high cardiovascular diseases (CVD) risk. This is a retrospective cohort study using Taiwan’s Health and Welfare Database. A total of 1057 patients treated with liraglutide were identified and matched with 4600 patients treated with basal insulin. The liraglutide group had a lower risk of a composite CVD outcome (hazard ratio (HR) 0.65; 95% confidence interval (CI) 0.50–0.85; p < 0.01), all-cause mortality (HR 0.40; 95% CI 0.28–0.59; p < 0.0001), and nonfatal stroke (HR 0.54; 95% CI 0.34–0.87; p = 0.01). Compared to the basal insulin group, the liraglutide group had lower median per-patient-per-month (PPPM) inpatient, emergency room (ER), and total medical costs, but higher median PPPM outpatient, total pharmacy, and total costs (all p < 0.0001). In conclusion, compared to basal insulin, liraglutide was found to be associated with reduced risk of a composite CVD outcome, nonfatal stroke, and all-cause mortality among high CVD risk patients with T2DM. In addition, liraglutide users had lower inpatient, ER, and total medical costs, but they had higher outpatient and total pharmacy costs.
Funder
Taipei Medical University
Publisher
Springer Science and Business Media LLC
Reference29 articles.
1. Cho, N. H. et al. IDF Diabetes atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res. Clin. Pract. 138, 271–281 (2018).
2. Ogurtsova, K. et al. IDF Diabetes atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res. Clin. Pract. 128, 40–50 (2017).
3. Holman, N., Young, B. & Gadsby, R. Current prevalence of type 1 and type 2 diabetes in adults and children in the UK. Diabetes Med. 32, 1119–1120 (2015).
4. Ministry of Health and Welfare. 2018 National Health Insurance Annual Statistical Report of Medical Care (2018) (accessed 10 May 2020); https://dep.mohw.gov.tw/DOS/cp-4649-50677-113.html.
5. Sheen, Y.-J. et al. Trends in prevalence and incidence of diabetes mellitus from 2005 to 2014 in Taiwan. J. Formos Med. Assoc. 118(Suppl 2), S66–S73 (2019).
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