Author:
Monfort Sandra,Orellana Carmen,Oltra Silvestre,Rosello Mónica,Caro-Llopis Alfonso,Martinez Francisco
Abstract
AbstractDevelopment of assisted reproductive technologies to address infertility has favored the birth of many children in the last years. The majority of children born with these treatments are healthy, but some concerns remain on the safety of these medical procedures. We have retrospectively analyzed both the fertilization method and the microarray results in all those children born between 2010 and 2019 with multiple congenital anomalies, developmental delay and/or autistic spectrum disorder (n = 486) referred for array study in our center. This analysis showed a significant excess of pathogenic copy number variants among those patients conceived after in vitro fertilization with donor oocyte with respect to those patients conceived by natural fertilization (p = 0.0001). On the other hand, no significant excess of pathogenic copy number variants was observed among patients born by autologous oocyte in vitro fertilization. Further studies are necessary to confirm these results and in order to identify the factors that may contribute to an increased risk of genomic rearrangements, as well as consider the screening for genomic alterations after oocyte donation in prenatal diagnosis.
Funder
Fundacion Mutua Madrileña
Publisher
Springer Science and Business Media LLC
Reference21 articles.
1. Hansen, M. et al. Intellectual disability in children conceived using assisted reproductive technology. Pediatrics 142(6), e20181269. https://doi.org/10.1542/peds.2018-1269 (2018).
2. Uyar, A. & Seli, E. The impact of assisted reproductive technologies on genomic imprinting and imprinting disorders. Curr. Opin. Obstet. Gynecol. 3, 210–221 (2014).
3. Scherrer, U., Rexhaj, E., Allemann, Y., Sartori, C. & Rimoldi, S. F. Cardiovascular dysfunction in children conceived by assisted reproductive technologies. Eur. Heart J. 25, 1583–1589 (2015).
4. Wijers, C. H. et al. Genetic and nongenetic etiology of nonsyndromicanorectal malformations: a systematic review. Birth Defects Res. C Embryo Today 102, 382–400 (2014).
5. Rimoldi, S. F. et al. Vascular dysfunction in children conceived by assisted reproductive technologies: underlying mechanisms and future implications. Swiss Med. Wkly. 25, 13973 (2014).
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献