Author:
Delespaul Lucile,Gélabert Caroline,Lesluyes Tom,Le Guellec Sophie,Pérot Gaëlle,Leroy Laura,Baud Jessica,Merle Candice,Lartigue Lydia,Chibon Frédéric
Abstract
AbstractCell–cell fusion is a physiological process that is hijacked during oncogenesis and promotes tumour evolution. The main known impact of cell fusion is to promote the formation of metastatic hybrid cells following fusion between mobile leucocytes and proliferating tumour cells. We show here that cell fusion between immortalized myoblasts and transformed fibroblasts, through genomic instability and expression of a specific transcriptomic profile, leads to emergence of hybrid cells acquiring dissemination properties. This is associated with acquisition of clonogenic ability by fused cells. In addition, by inheriting parental properties, hybrid tumours were found to mimic the histological characteristics of a specific histotype of sarcomas: undifferentiated pleomorphic sarcomas with incomplete muscular differentiation. This finding suggests that cell fusion, as macroevolution event, favours specific sarcoma development according to the differentiation lineage of parent cells.
Funder
Fondation Recherche Médicale
Association pour la Recherche contre le Cancer
Association Phil’Anthrope
Association Pour Corentin
Publisher
Springer Science and Business Media LLC
Reference56 articles.
1. Aguilar, P. S. et al. Genetic basis of cell–cell fusion mechanisms. Trends Genet. 29, 427–437 (2013).
2. Dittmar, T. & Zänker, K. S. Introduction. In Cell Fusion in Health and Disease, Vol. 950 (eds Dittmar, T. & Zänker, K. S.) 1–3 (Springer, Dordrecht, 2011).
3. Ogle, B. M., Cascalho, M. & Platt, J. L. Biological implications of cell fusion. Nat. Rev. Mol. Cell Biol. 6, 567–575 (2005).
4. Duelli, D. & Lazebnik, Y. Cell fusion: A hidden enemy?. Cancer Cell 3, 445–448 (2003).
5. Bastida-Ruiz, D., Van Hoesen, K. & Cohen, M. The dark side of cell fusion. Int. J. Mol. Sci. 17, 638 (2016).
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献