Properties of odor identification testing in screening for early-stage Alzheimer’s disease

Author:

Audronyte Egle,Pakulaite-Kazliene Gyte,Sutnikiene Vaiva,Kaubrys Gintaras

Abstract

AbstractOdor identification (OI) is impaired in the early stages of Alzheimer’s disease (AD). However, data regarding the diagnostic properties of OI tests are lacking, preventing their clinical use. We aimed to explore OI and determine the accuracy of OI testing in screening for patients with early AD. In total, 30 participants with mild cognitive impairment due to AD (MCI-AD), 30 with mild dementia due to AD (MD-AD), and 30 cognitively normal elderly participants (CN) were enrolled, and cognitive examination (CDR, MMSE, ADAS-Cog 13, and verbal fluency tests) and assessment of OI (Burghart Sniffin’ Sticks odor identification test) were performed. MCI-AD patients scored significantly worse in OI than CN participants, and MD-AD patients had worse OI scores than MCI-AD patients. The ratio of OI to ADAS-Cog 13 score had good diagnostic accuracy in differentiating AD patients from CN participants and in differentiating MCI-AD patients from CN participants. Substitution of ADAS-Cog 13 score with the ratio of OI to ADAS-Cog 13 score in a multinomial regression model improved the classification accuracy, especially of MCI-AD cases. Our results confirmed that OI is impaired during the prodromal stage of AD. OI testing has a good diagnostic quality and can improve the accuracy of screening for early-stage AD.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference40 articles.

1. Global Status Report on the Public Health Response to Dementia (World Health Organization, Geneva, 2021). Licence: CC BY-NC-SA 3.0 IGO.

2. Gauthier, S., Rosa-Neto, P., Morais, J. A. & Webster, C. World Alzheimer Report 2021: Journey through the Diagnosis of Dementia (Alzheimer’s Disease Int., London, England, 2021).

3. Global Action Plan on the Public Health Response to Dementia 2017–2025 (World Health Organization, Geneva, 2017). Licence: CC BY-NC-SA 3.0 IGO.

4. Albert, M. S. et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 7, 270–279 (2011).

5. McKhann, G. M. et al. The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 7, 263–269 (2011).

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