Ceftriaxone resistance among patients at GAMBY teaching general hospital

Abstract

AbstractCeftriaxone is a broad spectrum of widely used antibiotics as it is highly effective against Gram-negative and Gram-positive isolates. Research on Ceftriaxone resistance helps to know its current status. Hence, we aimed to identify the prevalence of Ceftriaxone resistance on bacteria isolated from clinical specimens among patients at GAMBY Teaching General Hospital Bahir Dar, Ethiopia. Hospital-based retrospective cross-sectional study was conducted at GAMBY teaching General Hospital from November 01, 2015, to December 30, 2020, on 402 clinical specimens. Ceftriaxone susceptibility tests were carried out using the Kirby-Bauer disc diffusion method. Descriptive statistics and chi-square tests were applied for the analysis. Escherichia coli 114 (28.4%), S. aureus 90 (22.4%), S. saprophyticus 42 (10.4%), and Klebsiella spp 42 (10.4%) were the predominant identified bacteria. The overall resistance of ceftriaxone was 230 (57.2%). Sex and type of the clinical specimens had significantly associated with its resistance whereas age was not associated with ceftriaxone resistance. Ceftriaxone resistance has been steadily increasing. Ceftriaxone resistance was high. Sex and type of the clinical specimens had significantly associated with its resistance. Prevention mechanisms to ceftriaxone resistance should be strictly implemented. The right drugs should be selected based on susceptibility patterns.