Author:
Ramezani Mehrafarin,Mouches Pauline,Yoon Eunjin,Rajashekar Deepthi,Ruskey Jennifer A.,Leveille Etienne,Martens Kristina,Kibreab Mekale,Hammer Tracy,Kathol Iris,Maarouf Nadia,Sarna Justyna,Martino Davide,Pfeffer Gerald,Gan-Or Ziv,Forkert Nils D.,Monchi Oury
Abstract
AbstractCognitive impairments are prevalent in Parkinson’s disease (PD), but the underlying mechanisms of their development are unknown. In this study, we aimed to predict global cognition (GC) in PD with machine learning (ML) using structural neuroimaging, genetics and clinical and demographic characteristics. As a post-hoc analysis, we aimed to explore the connection between novel selected features and GC more precisely and to investigate whether this relationship is specific to GC or is driven by specific cognitive domains. 101 idiopathic PD patients had a cognitive assessment, structural MRI and blood draw. ML was performed on 102 input features including demographics, cortical thickness and subcortical measures, and several genetic variants (APOE, MAPT, SNCA, etc.). Using the combination of RRELIEFF and Support Vector Regression, 11 features were found to be predictive of GC including sex, rs894280, Edinburgh Handedness Inventory, UPDRS-III, education, five cortical thickness measures (R-parahippocampal, L-entorhinal, R-rostral anterior cingulate, L-middle temporal, and R-transverse temporal), and R-caudate volume. The rs894280 of SNCA gene was selected as the most novel finding of ML. Post-hoc analysis revealed a robust association between rs894280 and GC, attention, and visuospatial abilities. This variant indicates a potential role for the SNCA gene in cognitive impairments of idiopathic PD.
Funder
Parkinson Association of Alberta
Canada Foundation for Innovation John R Evans Leaders
Fonds de recherche du Québec-Santé (FRQS) Chercheurs-boursiers
River Fund at Calgary Foundation
Canada Research Chair program
Canadian Institutes of Health Research
Tourmaline Oil Chair in Parkinson's Disease
Publisher
Springer Science and Business Media LLC
Cited by
7 articles.
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