Author:
Su Hsu-Han,Sung Fung-Chang,Kao Kai-Liang,Chen Shu-Chin,Lin Chen-Ju,Wu Shu-I,Lin Cheng-Li,Stewart Robert,Chen Yi-Shin
Abstract
AbstractIncreased prevalence of sleep disorders has been found in patients with functional dyspepsia; however, direction of causality remains unclear. Our aim was to compare the risk of incident functional dyspepsia between patients with and without sleep disturbance from a large population-based sample. Utilizing a nation-wide health insurance administrative dataset, we assembled an 11-year historic cohort study to compare subsequent incidence of diagnosed functional dyspepsia between adult patients with any diagnosis of sleep disturbance and age- and gender-matched controls. Hazard ratios adjusted for other relevant comorbidities and medications were calculated using Cox regression models. 45,310 patients with sleep disorder and 90,620 controls were compared. Patients with sleep apnea had a 3.3-fold (95% confidence interval: 2.82 ~ 3.89) increased hazard of functional dyspepsia compared with controls. This increased risk persisted regardless of previously diagnosed depression coexisted. Sleep disturbance was associated with an increased risk of subsequent functional dyspepsia. Potential mechanisms are discussed.
Publisher
Springer Science and Business Media LLC
Reference45 articles.
1. Fernandez-Mendoza, J. & Vgontzas, A. N. Insomnia and its impact on physical and mental health. Curr. Psychiatry Rep. 15(12), 8 (2013).
2. Ohayon, M. M. Epidemiology of insomnia: What we know and what we still need to learn. Sleep Med. Rev. 6(2), 15 (2002).
3. Schillinger, E., Kushida, C., Fahrenbach, R., Dement, W. & LeBaron, S. Teaching family medicine medical students about sleep disorders. Fam. Med. 35(8), 3 (2003).
4. Sofi, F. et al. Insomnia and risk of cardiovascular disease: A meta-analysis. Eur. J. Prev. Cardiol. 21(1), 8 (2014).
5. Morgenstern, M. et al. Obstructive sleep apnea: An unexpected cause of insulin resistance and diabetes. Endocrinol. Metab. Clin. North Am. 43(1), 18 (2014).
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献