Author:
Franzén Anna,Pikkemaat Miriam,Melander Olle,Bennet Louise,Enhörning Sofia
Abstract
AbstractIraqi born immigrants in Sweden have higher prevalence of metabolic diseases compared to native Swedes. Copeptin, a marker for vasopressin, is associated with increased risk of metabolic disease. In this cross-sectional population study based on the MEDIM cohort we investigated differences in copeptin levels between Iraqi and Swedish born individuals and if the association between copeptin and cardiometabolic risk markers differed by region of origin. We included 1109 Iraqi and 613 Swedish born participants (58% men, mean age 47 years). The Swedish participants had a higher concentration of copeptin compared to the Iraqi born group after age and sex adjustment (p < 0.001). This difference existed only among male individuals with the highest copeptin concentrations, i.e. belonging to copeptin quartile 4 (median (25th; 75th percentile) 20.07 (15.27;33.28) pmol/L for the Swedish born versus 15.57 (13.91;19.00) pmol/L for the Iraqi born, p < 0.001). We found a significant interaction between copeptin (continuous ln-transformed) and being born in Iraq regarding the association with plasma triglycerides (Pinteraction = 0.006). The association between copeptin and BMI was stronger amongst the Iraqi born individuals compared to the Swedish born. Together, this could indicate that copeptin is a more potent marker of metabolic disease among individuals born in Iraq compared to Sweden.
Funder
Lund University
ALF grant, Lund University
ALF grants, Lund University
Linné grant, Swedish Research Council
Exodiab, Swedish Research Council
The Swedish foundation for Strategic Research
The Swedish Research council
The Swedish society for medical research
The Åke Wiberg foundation
The Maggie Stephen foundation
The Albert Påhlsson foundation
Crafoordska Stiftelsen
The Swedish society of medicine
The Swedish heart and lung foundation
Skånes universitetssjukhus
Publisher
Springer Science and Business Media LLC